It’s there, at the start of every conversation: the moment it takes your brain to adjust to an unfamiliar voice. It only lasts for a second or two, but in that brief time, your brain is thumbing its radio dial, tuning in to the unique pitch, rhythm, accent,and vowel sounds of a new voice. Once it is dialed in, the conversation can [46](1.make out 2. take off 3. getup).
This process is called rapid neural adaptation, and it happens constantly.New voices, sounds, sights, feelings, tastes, and smells all trigger this brain response. It is so [47](1.effortless 2. demanding 3. intrusive) that we are rarely even aware it’s happening.But, according to new work from Tyler Perrachione and colleagues, problems with neural adaptation may be at the root of dyslexia, a reading impairment that affects millions ofAmericans, including[48](1. an estimated 2. as few as 3. precisely) one-in-five to one-in-twenty schoolchildren. Their experiments are the first to use brain imaging to compare neural adaptation in the brains of people with dyslexia and those who read normally.
In the team’s first experiment,volunteers without dyslexia were asked to pair spoken words with images on a screen while the researchers used functional magnetic resonance imaging (fMRI) to [49](1.support 2. enhance 3. track) their brain activity.The subjects tried the test two different ways. In one version, they listened to words spoken by a variety of different voices. In the second version, they heard the words all spoken by the same voice. As the researchers expected, the fMRI revealed an [50](1.initial 2. urgent 3. inverted) spike of activity in the brain’s language network at the start of both tests. But during the first test,the brain continued revving with each new word and voice. When the voice stayed the same in the second test,the brain did not have to work as hard. It adapted.
When subjects with dyslexia took the same tests, however, their brain activity never eased off. Like a radio that can’t hold a frequency, the brain did not adapt to the consistent voice and had to process it fresh everytime, as if it were new.
The results suggest that dyslexic brains have to work harder than “typical” brains to process incoming sights and sounds, [51](1.limiting 2. avoiding 3. requiring) additional mental overhead for even the simplest tasks. “What was surprising for me was the magnitude of the difference. These are not subtle differences,” says Perrachione. This finding dovetails with his other work on the dyslexic brain, which has found that individuals with dyslexia also struggle with phonological working memory.The extra brainwork might not be noticeable most of the time, but it seems to have a singularly prominent impact on reading.
The results could solve a paradox that has [52](1. stumped 2. enlightened 3. implicated) dyslexia researchers for decades. “People with dyslexia have a specific problem with reading,yet there is no ‘reading part’ of our brain,” says MIT neuroscientist John Gabrieli. Injuries to specific parts of the brain can cause people to lose particular skills, like the ability to speak, that sit in those brain regions. But because the brain doesn’t have a discrete reading center, it’s hard to understand how a disorder could [53](1.tackle 2. injure 3. handicap)reading and only reading.
This new work partially solves the paradox because rapid neural adaptation is a “low-level” function of the brain, which acts as a [54](1.chopping 2. mounting 3. building)block for “higher-level”, abstract functions. Yet that opens up another mistery ,says Gabrieli:”Why are there other domains that are so well done by people with reading difficulty?”
The answer [55](1.has stuck 2. has to do 3. has problems) with the way we learn to read, the researchers think.There’s almost nothing we lean1 that’s as complicated as reading.That’s because learning to read is mentally cumbersome. The hu1nan brain did not evolve to read – literacy has been commonplace only in the last two centuries – so the brain must repurpose regions that evolved for very different ends. And the evolutionary newness of reading may leave the brain without a backup plan. “Reading is so demanding that there’s not a successful alternative pathway that works as well,” says Gabrieli.It’s like using a stapler to pound a nail – the stapler can get the job done, but it takes a lot of extra effort.
The fMRI results show which parts of the brain are straining but don’t tell researchers exactly why people with dyslexia have a different adaptation response. “Finding a basic thing that’s true in the whole brain gives us a better opportunity to start looking for connections between biological models and psychological models,” says Perrachione. Those connections, may one day lead to better ways to identify and treat kids with dyslexia.
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